IV/IM Administration. {{configCtrl2.info.metaDescription}} Sign up today to receive the latest news and updates from UpToDate. By mouth or by injection into a vein, it is used to treat meningitis, plague, cholera, and typhoid fever. Reconstitute with sterile water for injection or bacteriostatic water for injection. PO (Adults): 2080 mg/day as a single dose initially, may repeat in 68 hr; may dose by 2040 mg every 68 hr until desired response.Maintenance doses may be given once or twice daily (doses up to 2.5 g/day have been used in patients with HF or renal disease). Renal impairment: Dose adjustment not necessary. Pharmacokinetics (from Ancient Greek pharmakon "drug" and kinetikos "moving, putting in motion"; see chemical kinetics), sometimes abbreviated as PK, is a branch of pharmacology dedicated to determining the fate of substances administered to a living organism. Warnings. Intravenous injection is often asymptomatic. Tortoises: Give in front legs only, up to 21 days (Lancaster, pers comm, 1997). Mild Infections With Gram-Positive Cocci. IM: reconstitute vial with 2 mL SWI , NS, or procaine HCl 1% solution. IM: give deep into upper outer quadrant of gluteal muscles 250 mg/ig IV, IM bid. Renal impairment (IV) CrCl 25-50 mL/min/1.73 m: Give recommended dose q12hr; CrCl 10-25 mL/min/1.73 m: Give recommended dose q24hr amikacin. Next: Images. IV Administration. 0.5-1 g IV q6-8hr. Preparation for Surgery. A nurse is preparing to administer amikacin 7/mg/kg/day IM to a client who weighs 165 pounds. 80 mg/kg (up to 2 g) once daily in conjunction with IV amikacin (20 mg/kg daily) has been used. Dosage. Solution: Rapid direct injection: dilute vial to max of 2 mg/mL; Infusion: dilute vial to max of 1 mg/mL; IV Administration. c) any other container for substances for therapeutic use having a nominal capacity of ten millilitres or less. trazodone will decrease the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. To reduce pain associated with injection, use larger veins of forearm or antecubital fossa; lidocaine IV (1 mL of a 1% solution) may also be used prior to administration 250-500 mg IV q8hr. Dosage forms: TAB: 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg, 20 mg, 30 mg Special Note [formulation clarification] Info: Adderall may be switched to Adderall XR at equivalent total daily dose; not interchangeable w/ Mydayis, do not substitute on a mg to mg basis How many mL should the nurse administer per dose? Injection. 1-2 g IV q8-12hr for 7-10 days (if not caused by Pseudomonas) or for up to 21 days (if caused by Pseudomonas) Give IM only in mild-to-moderate UTI due to E coli. IV maintenance: 25% of initial effective dose PRN by slow titration. Solid is considered to include powder for the purposes of scheduling. Clinical deficits can occur after intra-arterial injection of only small volumes of air. Skin irritation or formation of sterile abscesses after subcutaneous injection of antibiotics like penicillin or enrofloxacin (Baytril) is possible.When the antibiotic is dissolved in a water-based solution, e.g., enrofloxacin, the formation of sterile abscesses can be avoided by diluting the amount to be given by the same amount of a sterile saline solution. IV/IM/IT Preparation. Its use by mouth or by injection is only recommended when safer antibiotics cannot be used. In patients who are treated with the combination of an IV beta-lactam and a macrolide who have risk factors for drug-resistant S. pneumoniae (DRSP), we replace the IV beta-lactam with high-dose amoxicillin (1 g orally three times daily) to complete the course of therapy. Sign Up cefTRIAXone for Injection, for IV Infusion (available in dual-chambered Duplex drug delivery system with 3.74% dextrose injection) B Braun. The CDC lists drug-resistant Neisseria gonorrhoeae as an "urgent" threat; its highest level of concern. Adult Dosing . Amikacin is injected into a muscle, or into a vein through an IV. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine. Rapid IV infusion or injection associated with hypotension and must be avoided. Not for use in patients with symptomatic decompensated heart failure occurring within 4 weeks, requiring hospitalization or NYHA Class III or IV symptoms. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, Presentation. SMX-TMP remains the treatment of choice, but other sulfa antibiotics (eg, sulfadiazine and sulfasoxazole), amikacin, imipenem, meropenem, third-generation cephalosporins (ceftriaxone and cefotaxime), minocycline, extended-spectrum fluoroquinolones (eg, moxifloxacin), linezolid, and dapsone are effective in vitro and in animal models (Table 6). This medication is given by injection into a muscle or vein as directed by your doctor. Injection: Inject directly or into tubing of actively running IV over 1-2 minutes. In certain high-risk conditions (e. g. in case of severe renal impairment) high serum levels and oto- and nephrotoxic effects can occur. Amikacin is usually given for 7 to 10 days. Edema. IV Injection: 1 ml per 15 kg body weight. Mild to moderate hepatic impairment: Dose adjustment not necessary. Prophylaxis against infection. c) any other container for substances for therapeutic use having a nominal capacity of ten millilitres or less. IV Administration. Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. Solid is considered to include powder for the purposes of scheduling. Dosage of oral and IV levofloxacin is identical. trazodone will decrease the level or effect of amikacin by P-glycoprotein (MDR1) efflux transporter. ITEM: SPECIFICATION: Adrenaline Injection: 1mg/1ml: Amikacin Injection: 250mg/2ml, 500mg/2ml: Aminophylline Injection Vaccination is a great way to give your pet immunity to some of these infectious diseases, and make sure they are as safe as they can be. a) an injection vial having a nominal capacity of ten millilitres or less; b) a single use syringe; or. Does not need to be diluted (available form: 10 mg/mL); however, may be further diluted in D5W to 2 mg/mL. Previous. Administration of a total of 56 g during 10 days to an adult resulted in renal insufficiency. IV Preparation. Modify Therapy/Monitor Closely. amikacin and vancomycin both increase nephrotoxicity and/or ototoxicity. Dosing Modifications. Administer doses of 250 or 500 mg by IV infusion over 60 minutes; administer doses of 750 mg by IV infusion over 90 minutes. Use 5 mL for 125 mg, 250 mg, or 500 mg vials; 7.4 mL for 1 g vials; or 14.8 mL for 2 g vials. Severe hepatic impairment: Containdicated IV: infuse over 60-90 min. Syringe: Amikacin, aztreonam, caffeine, gentamicin, heparin 150 mg/mL solution for injection must be diluted before infused IV. BRAND FORM. Mild-to-Moderate Cholecystitis. IV Administration. Tell your veterinarian if your pet or horse is being given digoxin (Lanoxin), steroids (such as prednisone), other blood pressure medications, Amikacin, gentamicin, tobramycin, salicylates such as aspirin (Vetrin), or indomethacin. Injection of up to 0.5-1 mL/kg has been tolerated in experimental animals. amikacin; gentamicin; tobramycin An IV infusion is a type of injection. The organ system most commonly affected includes the respiratory system, the Use Caution/Monitor. Recommended treatment in the U.S. is a single 500 mg intramuscular injection of ceftriaxone (no longer combined with azithromycin due to resistance). They can give you tips on how to deal with any side effects that may be bothersome. If you give your pet or horse sucralfate (Carafate), give it at least 2 hours before or after giving furosemide. 1-2 g IV q8hr for 4-7 days. Continuous IV infusion. May give continuous IV infusion instead of intermittent after first dose has been given by rapid IV infusion; Available is amikacin 250 mg/mL solution for injection. IV: dilute 500,000 U in 300-500 mL D5W. IV Preparation. Administer undiluted IV injections at rate of 20-40 mg/min; not to exceed 4 mg/min for short-term intermittent infusion; in children, give 0.5 mg/kg/min, titrated to IV (>60 years): 1-1.5 mg initially; not to exceed >1.5 mg in 2 min period; may repeat with 1 mg/dose q2-3min PRN; not to exceed cumulative dose of 3.5 mg; peak effect may be delayed in elderly, so increments should be smaller and rate of injection slower. Call your doctor right away if you have numbness, tingling, muscle twitching, dizziness, spinning sensation, seizure (convulsions), hearing loss, or a ringing or roaring sound in your ears (even after you have stopped using tobramycin injection).. Tobramycin can also Visit our complete library of health topics, with coverage information, policies and more. (66) In humans, continuous IV infusion of oxygen at 10 mL/min has been reported as well tolerated, while 20 mL/min caused symptoms. Infusion: dilute vial to max of 1 mg/mL. Autonomic dysreflexia is a condition that emerges soon after a spinal cord injury, usually when the damage has occurred at or above the T6 level. This includes use as an eye ointment to treat conjunctivitis. Rapid direct injection: dilute vial to max of 2 mg/mL. You may be shown how to use an IV at home. (Round the answer to the nearest tenth. Use Caution/Monitor. Use initial dilution within 1 hr. Store at room temp. Dosing Considerations Toxicity due to overdose has been reported. Tobramycin can damage nerves and may cause hearing loss that may be permanent. Use a leading zero if it applies. You should not use gentamicin if you are allergic to gentamicin or similar antibiotics such as amikacin, kanamycin, neomycin, paromomycin, streptomycin, Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine. Give a 1 gram dose of ceftriaxone in patients who weigh 150 kg or more. Intrathecal (IT): reconstitute vial with10 mL NS; DO NOT use procaine HCl for IT. amitriptyline. Storage. Tuberculosis (TB) is an ancient human disease caused by Mycobacterium tuberculosis which mainly affects the lungs, making pulmonary disease the most common presentation (K Zaman, 2010) [1]. amikacin. After 20 mg/kg IV loading dose, give maintenance dose according to gestational age (GA) and serum creatinine (Scr) amikacin. However, TB is a multi-systemic disease with a protean presentation. Dilute 300 and 600 mg in 50 mL of D5W. acyclovir and amikacin both increase nephrotoxicity and/or ototoxicity. 1 g IV q12hr. amitriptyline and trazodone both decrease cholinergic effects/transmission. Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis (M-TB), an acid-fast aerobic bacteria that can grow on gram stain Dosage adjustments not needed when switching from IV to oral administration. It is generally defined as a syndrome in susceptible spinal cord injured patients that incorporates a sudden, exaggerated reflexive increase in blood pressure in response to a stimulus, usually bladder or bowel Amikacin (amiglyde sulfate) 5 mg/kg IM, then 2.5 mg/kg IM q 72 hr: Highly nephrotoxic - give with SC/IC fluids Baytil with making a more palatable medicine that is easier and safer to administer than by injection. Give intermittent IV infusions over 30 minutes (except neonates). a) an injection vial having a nominal capacity of ten millilitres or less; b) a single use syringe; or. Uncomplicated Urinary Tract Infection. Give either as a rapid direct injection or as an infusion. Antitubercular medications: rifampin, isoniazid, pyrazinamide, and ethambutol are FDA approved to treat Mycobacterium tuberculosis infections. 500 mg iv to a child, 2 year of age, resulted in lethal intoxication. Do not use a trailing zero.) Antitubercular medications are a group of drugs used to treat tuberculosis.